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血清Chemerin在糖尿病视网膜病变患者中的表达及临床意义

时间:2015-10-21 10:58来源:未知 作者:admin 点击:
引用: 杨靖,聂鹏,杭春玖.血清Chemerin在糖尿病视网膜病变患者中的表达及临床意义.国际眼科杂志 2015;15(10):1717-1719,doi:10.3980/j.issn.1672-5123.2015.10.10 Reference: Yang J,Nie P,Hang CJ.Expression of serum Chemerin in the diabetic retinopathy
引用:杨靖,聂鹏,杭春玖.血清Chemerin在糖尿病视网膜病变患者中的表达及临床意义.国际眼科杂志 2015;15(10):1717-1719,doi:10.3980/j.issn.1672-5123.2015.10.10
Reference:Yang J,Nie P,Hang CJ.Expression of serum Chemerin in the diabetic retinopathy patients and its clinical implication.Guoji Yanke Zazhi( Int Eye Sci) 2015;15(10):1717-1719,doi:10.3980/j.issn.1672-5123.2015.10.10
血清Chemerin在糖尿病视网膜病变患者中的表达及临床意义
Expression of serum Chemerin in the diabetic retinopathy patients and its clinical implication
投稿时间: 2015-05-08  最后修改时间: 2015-09-07
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DOI:10.3980/j.issn.1672-5123.2015.10.10
关键词:  糖尿病视网膜病变  Chemerin  糖尿病
Key Words:  diabetic retinopathy  Chemerin  diabetes mellitus
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作者 单位
杨靖 中国江苏省扬州市第一人民医院眼科
聂鹏 中国山东省济南市,济南钢铁集团有限公司总医院
杭春玖 中国江苏省扬州市第一人民医院眼科
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摘要:
      目的:观察糖尿病视网膜病变(diabetic retinopathy,DR)患者血清Chemerin 水平变化,探讨其在DR发生发展过程中的作用。

 

     方法:采用临床病例对照研究,以2012-01/2013-12期间就诊的90例糖尿病患者为研究对象,分为糖尿病无视网膜病变(no diabetic retinopathy,NDR)组、单纯型糖尿病视网膜病变(simple diabetic retinopathy,SDR)组和增殖型糖尿病视网膜病变(proliferative diabetic retmopathy,PDR)组三组,以健康志愿者(normal controls,NC)为对照组,采用双抗体夹心法酶联免疫吸附法检测患者血清中Chemerin水平,同时检测TNF-α、脂联素等炎症因子水平,收集患者体重指数、血脂、基础疾病等临床资料。

 

     结果:NC组、NDR组、SDR组和PDR组患者血清Chemerin依次为12.35±3.56、26.50±5.34、34.67±7.72、 40.97±8.97μg/L,SDR组、PDR血清Chemerin水平明显高于NC组和NDR组,差异有统计学意义(P<0.01),血清Chemerin水平与TNF-α正相关(r=0.8746,P<0.01),与脂联素负相关(r=-0.7418,P<0.01)。Logistic多元回归分析结果显示,Chemerin为DR独立危险因素之一(OR=8.458,95%CI:1.611~44.410,P=0.012)。

 

     结论:DR患者血清中Chemerin水平升高,其可能参与了DR的发生发展过程。

Abstract:
      AIM: To investigate the level changes of serum Chemerin in patients with diabetic retinopathy(DR)and explore its role in the development of DR.

 

     METHODS: A total of 90 diabetes patients from January 2012 to December 2013 were enrolled, including non-diabetic retinopathy(NDR,n=30), simple diabetic retinopathy(SDR, n=30), proliferative diabetic retinopathy(PDR, n=30). Thirty healthy persons were included as normal control(NC). Chemerin level, tumor necrosis factor-α(TNF-α), adiponectin were assessed by enzyme-linked immunosorbent assay.Clinical characters including BMI, underlying diseases, blood lipids ect. were collected.

 

     RESULTS: The serum levels of Chemerin in NC, NDR, SDR, and PDR group were 12.35±3.56, 26.50±5.34, 34.67±7.72, 40.97±8.97μg/L respectively. The serum levels of Chemerin in SDR and PDR group were significantly higher than those in NC and NDR group(P<0.01). Serum levels of Chemerin positively correlated with TNF-α(r=0.8746, P<0.01)and negatively correlated with adiponectin(r=-0.7418,P<0.01). The results of Logistic regression analysis showed that Chemerin was an independent risk factor for DR(OR=8.458, 95%CI: 1.611~44.410, P=0.012).

 

     CONCLUSION: The results show that serum Chemerin level is significantly elevated in DR patients, and Chemerin may be involved in the development of DR.

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