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引用:胡萍,金艳玲,王英,等.炎症因子在青光眼中的作用研究进展.国际眼科杂志 2015;15(12):2083-2086,doi:10.3980/j.issn.1672-5123.2015.12.15 |
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Reference:Hu P,Jin YL,Wang Y,et al.Progress of inflammatory cytokines in glaucoma.Guoji Yanke Zazhi( Int Eye Sci) 2015;15(12):2083-2086,doi:10.3980/j.issn.1672-5123.2015.12.15 |
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炎症因子在青光眼中的作用研究进展 |
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Progress of inflammatory cytokines in glaucoma |
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投稿时间： 2015-09-23 最后修改时间： 2015-11-23 |
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DOI：10.3980/j.issn.1672-5123.2015.12.15 |
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关键词: 青光眼 结缔组织生长因子 肿瘤坏死因子-α 白细胞介素 核转录因子-κB |
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Key Words: glaucoma connective tissue growth factor tumor necrosis factor-α interleukins nuclear factor-kappa B |
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摘要: |
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青光眼是一组具有特征性视神经损害和视野缺损的疾病，病理性眼压增高是其危险因素。青光眼是受多种基因的相互作用以及环境因素影响的疾病，近年来研究表明，炎症也可能参与青光眼的发病机制，大量研究已证实， 结缔组织生长因子(connective tissue growth factor，CTGF)、肿瘤坏死因子-α(tumor necrosis factor-α， TNF-α)、白细胞介素(interleukins，ILs)、核转录因子-kappa B(nuclear factor-kappa B，NF-κB)等多种细胞因子，在青光眼患者眼内房水中高表达，表明这些细胞因子与青光眼的发病机制有紧密的联系，本文就近年来有关炎症因子与青光眼关系的研究进展作一综述。
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Abstract: |
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Glaucomais a group of diseases characterized by optic nerve damage and visual field defect, and pathological high intraocular pressure is a risk factor for glaucoma. Glaucoma is affected by the interaction of multiple genes and environmental factors, and inflammation may be involved in the pathogenesis of glaucoma. A great deal of studies have confirmed that high expression of connective tissue growth factor(CTGF), tumor necrosis factor-α(TNF-α), interleukins(ILs), nuclear factor-kappa B(NF-κB)and various cytokines in the aqueous humor of patients with glaucoma, which have a close correlation with pathogenesis of glaucoma.This article reviews the progress of inflammatory cytokines and their relationship with glaucoma. |
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