国际眼科网 - 眼科专家交流中心!

国际眼科网

点击这里了解更多三焦点人工晶体信息
当前位置: 首页 > 学术论文 >

对比两种给药方案治疗急性视网膜坏死综合征患者的效果

时间:2016-07-22 10:40来源:未知 作者:国际眼科网编辑 点击:
对比两种给药方案治疗急性视网膜坏死综合征患者的效果 Comparison of two different drug therapies for acute retinal necrosis syndrome 投稿时间: 2016-01-28 最后修改时间: 2016-06-17 推荐文章 收藏文章 打印页面 DOI: 10.3980/j.issn.1672-5123.201
对比两种给药方案治疗急性视网膜坏死综合征患者的效果
Comparison of two different drug therapies for acute retinal necrosis syndrome
投稿时间: 2016-01-28  最后修改时间: 2016-06-17
推荐文章  收藏文章  打印页面
DOI:10.3980/j.issn.1672-5123.2016.7.43
关键词:  阿昔洛韦  醋酸泼尼松片  丙氧鸟苷  阿司匹林  急性视网膜坏死综合征
Key Words:  acyclovir  prednisone acetate tablets  ganciclovir  aspirin  acute retinal necrosis syndrome
基金项目:
Fund Project:
     
作者 单位
袁菁 中国湖北省武汉市第六医院眼科
胡维琨 中国湖北省武汉市同济医院眼科
摘要点击次数: 7
全文下载次数: 10
摘要:
      目的:探讨阿昔洛韦+醋酸泼尼松片、丙氧鸟苷+醋酸泼尼松片+阿司匹林两种给药方案治疗急性视网膜坏死综合征的临床疗效。

 

     方法:采用随机数字表法将我院急性视网膜坏死综合征患者30例40眼分为A、B两组,其中A组采用阿昔洛韦+醋酸泼尼松片的给药方案,B组采用丙氧鸟苷+醋酸泼尼松片+阿司匹林的给药方案,观察并比较两组患者治疗后的临床效果。

 

     结果:经过治疗后,B组总有效率(90%)明显高于A组(70%),两种给药方案均有效,差异无统计学意义(P>0.05); 两组患者在治疗前视力情况差异无统计学意义(P>0.05); 经不同给药方案治疗后,A组视力≥0.5者9眼,视力0.1~<0.5者3眼,视力0.02~<0.1者6眼,无感光者2眼,B组视力≥0.5者12眼,视力0.1~<0.5者4眼,视力0.02~<0.1者3眼,无感光者1眼, B组患者视力恢复情况优于A组,差异有统计学意义(P<0.05); B组患者视网膜裂孔、疱疹、口腔溃疡、水痘、病毒性脑炎及中枢神经病变等并发症的发生率(10%)明显低于A组(35%),差异有统计学意义(P<0.05)。

 

     结论:阿昔洛韦+醋酸泼尼松片、丙氧鸟苷+醋酸泼尼松片+阿司匹林两种给药方案都具有较为肯定的治疗效果,但后者对患者视力的恢复及并发症发生率的降低具有更好的优势。

Abstract:
      AIM: To investigate clinical efficacy of two drug therapies(acyclovir with prednisone acetate tablets, ganciclovir with prednisone acetate tablets and aspirin)for acute retinal necrosis syndrome.

 

     METHODS: Thirty patients(40 eyes)with acute retinal necrosis syndrome in our hospital were randomly divided into group A and B. Group A was treated with acyclovir with prednisone acetate tablets, and group B was given ganciclovir with prednisone acetate tablets and aspirin. Clinical effects in the two groups were observed and compared.

 

     RESULTS: After treatment, the overall response rate in group B(90%)was obviously higher than that in group A(70%), both of two regimens were effective, without significant difference(P>0.05). There was no significant difference on the pre-treatment visual acuity between the two groups(P>0.05). After different treatments, the visual acuity in group B was ≥0.5 in 12 eyes, 0.1≤and<0.5 in 4 eyes, 0.02≤and<0.1 in 3 eyes, and no photosensitive in 1 eye. The visual acuity in group A was ≥0.5 in 9 eyes, 0.1≤and<0.5 in 3 eyes, 0.02≤and<0.1 in 6 eyes, and no photosensitive in 2 eyes. The recovery of visual acuity in group B was obviously better than that in A group(P<0.05). The incidence of complications such as retinal tear, herpes, mouth ulcers, chickenpox, viral encephalitis and central nervous system diseases in group B(10%)was significantly lower than that in A group(35%,P<0.05).

 

     CONCLUSION: Two drug therapies(acyclovir with prednisone acetate tablets, ganciclovir with prednisone acetate tablets and aspirin)both have positive therapeutic effect, but the latter can better restore visual acuity and decrease the complications.

Citation Html:
查看全文  查看/发表评论  下载PDF阅读器

(责任编辑:国际眼科网编辑)
顶一下
(0)
0%
踩一下
(0)
0%
------分隔线----------------------------